Current RNA detection and quantification methods suffer from biases and errors, long running time, complicated protocols, low multiplexing and high cost. These problems are exacerbated for short non-coding RNA, such as miRNA, due to the need for enzymatic modifications of the target prior to processing.
Our Proprietary Technology Solution
With our proprietary nanostructure design technology, we are able to customise molecular probes that recognise specific nucleic acid molecules and detect them natively. Given a target RNA sequence, we design molecular probes that recognise the target. Specific signals from the resulting sample are then "digitised" by using a mature single-molecule readout technique.
This powerful technology, protected by two recently-filed patents, allows accurate, fast, high-multiplexed, simple, and most importantly direct measurement of the original target molecules without complicated sample processing. The platform technology not only overcomes current pain-points in RNA detection and quantification but is also suitable for the detection of other biomolecules such as DNA.